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Reaction mechanism of guanidinoacetate methyltransferase, concerted or step-wise
We describe a quantum mechanics/molecular mechanics investigation of the guanidinoacetate methyltransferase catalyzed reaction, which shows that proton transfer from guanidinoacetate (GAA) to Asp-134 and methyl transfer from S-adenosyl-l-methionine (AdoMet) to GAA are concerted. By self-consistent-c...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1637550/ https://ncbi.nlm.nih.gov/pubmed/17053070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607503103 |
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