BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility

BACKGROUND: The reciprocal (9;22) translocation fuses the bcr (breakpoint cluster region) gene on chromosome 22 to the abl (Abelson-leukemia-virus) gene on chromosome 9. Depending on the breakpoint on chromosome 22 (the Philadelphia chromosome – Ph+) the derivative 9+ encodes either the p40((ABL/BCR...

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Autores principales: Zheng, Xiaomin, Güller, Saskia, Beissert, Tim, Puccetti, Elena, Ruthardt, Martin
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2006
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1637115/
https://ncbi.nlm.nih.gov/pubmed/17090304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-6-262
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