A zidovudine-resistant simian immunodeficiency virus mutant with a Q151M mutation in reverse transcriptase causes AIDS in newborn macaques.

The simian immunodeficiency virus (SIV)-newborn rhesus macaque model of AIDS can be used to study directly the virulence of viral mutants which are resistant to antiviral drugs. A viral mutant called SIVmac79A6.1, isolated from an SIV-infected macaque after prolonged zidovudine treatment, was found...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Van Rompay, K K, Greenier, J L, Marthas, M L, Otsyula, M G, Tarara, R P, Miller, C J, Pedersen, N C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163702/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9021180/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.2.278
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