A zidovudine-resistant simian immunodeficiency virus mutant with a Q151M mutation in reverse transcriptase causes AIDS in newborn macaques.

The simian immunodeficiency virus (SIV)-newborn rhesus macaque model of AIDS can be used to study directly the virulence of viral mutants which are resistant to antiviral drugs. A viral mutant called SIVmac79A6.1, isolated from an SIV-infected macaque after prolonged zidovudine treatment, was found...

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Bibliografiske detaljer
Main Authors: Van Rompay, K K, Greenier, J L, Marthas, M L, Otsyula, M G, Tarara, R P, Miller, C J, Pedersen, N C
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC163702/
https://ncbi.nlm.nih.gov/pubmed/9021180
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