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Polysome-Bound Endonuclease PMR1 Is Targeted to Stress Granules via Stress-Specific Binding to TIA-1

The generalized process of mRNA decay involves deadenylation followed by release from translating polysomes, decapping, and exonuclease decay of the mRNA body. In contrast the mRNA endonuclease PMR1 forms a selective complex with its translating substrate mRNA, where it initiates decay by cleaving w...

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Autors principals: Yang, Feng, Peng, Yong, Murray, Elizabeth L., Otsuka, Yuichi, Kedersha, Nancy, Schoenberg, Daniel R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636822/
https://ncbi.nlm.nih.gov/pubmed/16982678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00090-06
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