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Endonuclease-mediated mRNA Decay Requires Tyrosine Phosphorylation of Polysomal Ribonuclease 1 (PMR1) for the Targeting and Degradation of Polyribosome-bound Substrate mRNA

PMR1 is an endonuclease that is activated by estrogen to degrade Xenopus albumin mRNA. A previous report showed that the functional unit of endonuclease-mediated mRNA decay is a ~680-kDa polysome-bound complex that contains both PMR1 and substrate mRNA. PMR1 contains two domains involved in endonucl...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yang, Feng, Peng, Yong, Schoenberg, Daniel R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1578673/
https://ncbi.nlm.nih.gov/pubmed/15375158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M409776200
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