Skeletal Muscle-Selective Knockout of LKB1 Increases Insulin Sensitivity, Improves Glucose Homeostasis, and Decreases TRB3

LKB1 is a tumor suppressor that may also be fundamental to cell metabolism, since LKB1 phosphorylates and activates the energy sensing enzyme AMPK. We generated muscle-specific LKB1 knockout (MLKB1KO) mice, and surprisingly, found that a lack of LKB1 in skeletal muscle enhanced insulin sensitivity,...

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Hauptverfasser: Koh, Ho-Jin, Arnolds, David E., Fujii, Nobuharu, Tran, Thien T., Rogers, Marc J., Jessen, Niels, Li, Yangfeng, Liew, Chong Wee, Ho, Richard C., Hirshman, Michael F., Kulkarni, Rohit N., Kahn, C. Ronald, Goodyear, Laurie J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636784/
https://ncbi.nlm.nih.gov/pubmed/16966378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00979-06
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