Ablation of LKB1 in the Heart Leads to Energy Deprivation and Impaired Cardiac Function

Energy deprivation in the myocardium is associated with impaired heart function and increased morbidity. LKB1 is a kinase that is required for activation of AMP-activated protein kinase (AMPK) as well as 13 AMPK-related protein kinases. AMPK stimulates ATP production during ischemia and prevents pos...

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Hauptverfasser: Jessen, Niels, Koh, Ho-Jin, Folmes, Clifford D., Wagg, Cory, Fujii, Nobuharu, Løfgren, Bo, Wolf, Cordula M., Berul, Charles I., Hirshman, Michael F., Lopaschuk, Gary D., Goodyear, Laurie J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893233/
https://ncbi.nlm.nih.gov/pubmed/20441792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2010.04.008
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