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DDB1 Maintains Genome Integrity through Regulation of Cdt1
DDB1, a component of a Cul4A ubiquitin ligase complex, promotes nucleotide excision repair (NER) and regulates DNA replication. We have investigated the role of human DDB1 in maintaining genome stability. DDB1-depleted cells accumulate DNA double-strand breaks in widely dispersed regions throughout...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1636754/ https://ncbi.nlm.nih.gov/pubmed/16940174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00819-06 |
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