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Correction of aberrant imprinting of IGF2 in human tumors by nuclear transfer-induced epigenetic reprogramming
Loss of genomic imprinting of insulin-like growth factor II (IGF2) is a hallmark of many human neoplasms. We attempted to correct this aberrant epigenotype by transferring nuclei from human tumor cells that showed loss of IGF2 imprinting into enucleated mouse and human fibroblasts that had maintaine...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1636609/ https://ncbi.nlm.nih.gov/pubmed/17082775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601399 |
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