Correction of aberrant imprinting of IGF2 in human tumors by nuclear transfer-induced epigenetic reprogramming

Loss of genomic imprinting of insulin-like growth factor II (IGF2) is a hallmark of many human neoplasms. We attempted to correct this aberrant epigenotype by transferring nuclei from human tumor cells that showed loss of IGF2 imprinting into enucleated mouse and human fibroblasts that had maintaine...

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Hlavní autoři: Chen, Hui Ling, Li, Tao, Qiu, Xin Wen, Wu, Jie, Ling, Jian Qun, Sun, Zhi Hong, Wang, Weibo, Chen, Wei, Hou, Aiju, Vu, Thanh H, Hoffman, Andrew R, Hu, Ji-Fan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636609/
https://ncbi.nlm.nih.gov/pubmed/17082775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601399
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