Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites

Indolicidin is a host defense tridecapeptide that inhibits the catalytic activity of HIV-1 integrase in vitro. Here we have elucidated its mechanism of integrase inhibition. Using crosslinking and mass spectrometric footprinting approaches, we found that indolicidin interferes with formation of the...

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Hauptverfasser: Marchand, Christophe, Krajewski, Krzysztof, Lee, Hsiu-Fang, Antony, Smitha, Johnson, Allison A., Amin, Ronak, Roller, Peter, Kvaratskhelia, Mamuka, Pommier, Yves
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2006
Schlagworte:
Molecular Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636436/
https://ncbi.nlm.nih.gov/pubmed/16998183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl667
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