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Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites
Indolicidin is a host defense tridecapeptide that inhibits the catalytic activity of HIV-1 integrase in vitro. Here we have elucidated its mechanism of integrase inhibition. Using crosslinking and mass spectrometric footprinting approaches, we found that indolicidin interferes with formation of the...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1636436/ https://ncbi.nlm.nih.gov/pubmed/16998183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl667 |
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