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Apparent cooperativity in the folding of multidomain proteins depends on the relative rates of folding of the constituent domains

Approximately 75% of eukaryotic proteins contain more than one so-called independently folding domain. However, there have been relatively few systematic studies to investigate the effect of interdomain interactions on protein stability and fewer still on folding kinetics. We present the folding of...

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Main Authors: Batey, Sarah, Clarke, Jane
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636339/
https://ncbi.nlm.nih.gov/pubmed/17108086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604580103
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