Assessment of the Relative Contribution of COX-1 and COX-2 Isoforms to Ischemia-induced Oxidative Damage and Neurodegeneration Following Transient Global Cerebral Ischemia

We investigated the relative contribution of COX-1 and/or COX-2 to oxidative damage, prostaglandin E(2) (PGE(2)) production and hippocampal CA1 neuronal loss in a model of 5 min transient global cerebral ischemia in gerbils. Our results revealed a biphasic and significant increase in PGE(2) levels a...

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Main Authors: Candelario-Jalil, Eduardo, González-Falcón, Armando, García-Cabrera, Michel, Álvarez, Dalia, Al-Dalain, Said, Martínez, Gregorio, Sonia León, Olga, Springer, Joe E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636020/
https://ncbi.nlm.nih.gov/pubmed/12859668
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