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Effects of nimesulide on kainate-induced in vitro oxidative damage in rat brain homogenates

BACKGROUND: The cyclooxygenase-2 inhibitor nimesulide is able to reduce kainate-induced oxidative stress in vivo. Here we investigate if this effect is mediated by the direct antioxidant properties of nimesulide using a well-characterized in vitro model of kainate toxicity. RESULTS: Exposure of rat...

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Detalhes bibliográficos
Main Authors: Candelario-Jalil, Eduardo, Sonia León, Olga
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC165434/
https://ncbi.nlm.nih.gov/pubmed/12807536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2210-3-7
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