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Assessment of the Relative Contribution of COX-1 and COX-2 Isoforms to Ischemia-induced Oxidative Damage and Neurodegeneration Following Transient Global Cerebral Ischemia
We investigated the relative contribution of COX-1 and/or COX-2 to oxidative damage, prostaglandin E(2) (PGE(2)) production and hippocampal CA1 neuronal loss in a model of 5 min transient global cerebral ischemia in gerbils. Our results revealed a biphasic and significant increase in PGE(2) levels a...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1636020/ https://ncbi.nlm.nih.gov/pubmed/12859668 |
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