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RNAi-mediated silencing of prohormone convertase (PC) 5/6 expression leads to impairment in processing of cocaine- and amphetamine-regulated transcript (CART) precursor

Understanding the functions of the widely expressed PCs (prohormone/proprotein convertases), including PC5/6, furin and PACE4 (paired basic amino acid cleaving enzyme 4), in animal models is difficult since individual knockouts of these PCs in mice exhibit early embryonic lethality. To investigate t...

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Библиографические подробности
Главные авторы: Stein, Jeffrey, Shah, Rohan, Steiner, Donald F., Dey, Arunangsu
Формат: Artigo
Язык:Inglês
Опубликовано: Portland Press Ltd. 2006
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635452/
https://ncbi.nlm.nih.gov/pubmed/16800814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060506
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