Organization of the Integrin LFA-1 in Nanoclusters Regulates Its Activity

The β2-integrin LFA-1 facilitates extravasation of monocytes (MOs) into the underlying tissues, where MOs can differentiate into dendritic cells (DCs). Although DCs express LFA-1, unlike MOs, they cannot bind to ICAM-1. We hypothesized that an altered integrin organization on the DC plasma membrane...

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Main Authors: Cambi, Alessandra, Joosten, Ben, Koopman, Marjolein, de Lange, Frank, Beeren, Inge, Torensma, Ruurd, Fransen, Jack A., Garcia-Parajó, Maria, van Leeuwen, Frank N., Figdor, Carl G.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2006
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635357/
https://ncbi.nlm.nih.gov/pubmed/16855029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-12-1098
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