Mutagenesis of diploid mammalian genes by gene entrapment

The present study describes a genome-wide method for biallelic mutagenesis in mammalian cells. Novel poly(A) gene trap vectors, which contain features for direct cloning vector–cell fusion transcripts and for post-entrapment genome engineering, were used to generate a library of 979 mutant ES cells....

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Bibliografiske detaljer
Main Authors: Lin, Qing, Donahue, Sarah L., Moore-Jarrett, Tracy, Cao, Shang, Osipovich, Anna B., Ruley, H. Earl
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2006
Fag:
Methods Online
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635309/
https://ncbi.nlm.nih.gov/pubmed/17062627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl728
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