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Carcinogens induce genome-wide loss of heterozygosity in normal stem cells without persistent chromosomal instability
Widespread losses of heterozygosity (LOH) in human cancer have been thought to result from chromosomal instability caused by mutations affecting DNA repair/genome maintenance. However, the origin of LOH in most tumors is unknown. The present study examined the ability of carcinogenic agents to induc...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1544223/ https://ncbi.nlm.nih.gov/pubmed/16868089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510741103 |
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