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Post-entrapment genome engineering: First exon size does not affect the expression of fusion transcripts generated by gene entrapment

Gene trap mutagenesis in mouse embryonic stem cells has been widely used for genome-wide studies of mammalian gene function. However, while large numbers of genes can be disrupted, individual mutations may suffer from limitations due to the structure and/or placement of targeting vector. To extend t...

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Detalhes bibliográficos
Main Authors: Osipovich, Anna B., Singh, Aparna, Ruley, H. Earl
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC551569/
https://ncbi.nlm.nih.gov/pubmed/15741512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.3258105
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