Continuous infusion of DL-alpha-difluoromethylornithine and improved efficacy against a rat model of Pneumocystis carinii pneumonia.

The rapid depletion of Pneumocystis carinii polyamines caused by in vitro exposure to DL-alpha-difluoromethylornithine (DFMO; also called eflornithine or Ornidyl) and the rapid repletion following removal of this drug suggested that the in vivo efficacy of DFMO against P. carinii pneumonia (PCP) may...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Chin, K, Merali, S, Sarić, M, Clarkson, A B
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163527/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8891137/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.10.2318
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