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Impact of Sample Size on the Performance of Multiple-Model Pharmacokinetic Simulations

Monte Carlo simulations are increasingly used to predict pharmacokinetic variability of antimicrobials in a population. We investigated the sample size necessary to provide robust pharmacokinetic predictions. To obtain reasonably robust predictions, a nonparametric model derived from a sample popula...

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Detalhes bibliográficos
Main Authors: Tam, Vincent H., Kabbara, Samer, Yeh, Rosa F., Leary, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635223/
https://ncbi.nlm.nih.gov/pubmed/16954312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00337-06
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