Population Analysis of Weight-, Age-, and Sex-Related Differences in the Pharmacokinetics of Lopinavir in Children from Birth to 18 Years

The pharmacokinetics of lopinavir were investigated by the use of a population approach performed with the nonlinear mixed effect modeling program NONMEM and 157 children ranging in age from 3 days to 18 years. The pharmacokinetics of lopinavir were well described by a one-compartment model in which...

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Hlavní autoři: Jullien, Vincent, Urien, Saïk, Hirt, Déborah, Delaugerre, Constance, Rey, Elisabeth, Teglas, Jean-Paul, Vaz, Paula, Rouzioux, Christine, Chaix, Marie-Laure, Macassa, Eugenia, Firtion, Ghislaine, Pons, Gérard, Blanche, Stéphane, Tréluyer, Jean-Marc
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2006
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635168/
https://ncbi.nlm.nih.gov/pubmed/16940058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00943-05
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