Reporter gene technology to assess activity of antimycobacterial agents in macrophages.

Reporter strains of Mycobacterium tuberculosis and Mycobacterium bovis BCG endogenously expressing firefly luciferase were used in bioluminescence assays to evaluate the activities of isoniazid and rifampin against mycobacteria sequestered in human macrophages. This methodology allowed the efficacy...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Arain, T M, Resconi, A E, Singh, D C, Stover, C K
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163365/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8726035/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.6.1542
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