In vitro trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors.

A series of novel aromatic derivatives based on the structure of methylglyoxal bis(guanylhydrazone) (MGBG) was examined for in vitro antitrypanosomal activities and cytotoxicities for human cells. One-third of the compounds tested showed trypanocidal activity at concentrations below 0.5 microM after...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Brun, R, Bühler, Y, Sandmeier, U, Kaminsky, R, Bacchi, C J, Rattendi, D, Lane, S, Croft, S L, Snowdon, D, Yardley, V, Caravatti, G, Frei, J, Stanek, J, Mett, H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163347/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8726017/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.6.1442
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