In vitro trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors.

A series of novel aromatic derivatives based on the structure of methylglyoxal bis(guanylhydrazone) (MGBG) was examined for in vitro antitrypanosomal activities and cytotoxicities for human cells. One-third of the compounds tested showed trypanocidal activity at concentrations below 0.5 microM after...

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Détails bibliographiques
Auteurs principaux: Brun, R, Bühler, Y, Sandmeier, U, Kaminsky, R, Bacchi, C J, Rattendi, D, Lane, S, Croft, S L, Snowdon, D, Yardley, V, Caravatti, G, Frei, J, Stanek, J, Mett, H
Format: Artigo
Langue:Inglês
Publié: 1996
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC163347/
https://ncbi.nlm.nih.gov/pubmed/8726017
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