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Assigning protein functions by comparative genome analysis: Protein phylogenetic profiles

Determining protein functions from genomic sequences is a central goal of bioinformatics. We present a method based on the assumption that proteins that function together in a pathway or structural complex are likely to evolve in a correlated fashion. During evolution, all such functionally linked p...

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書誌詳細
主要な著者: Pellegrini, Matteo, Marcotte, Edward M., Thompson, Michael J., Eisenberg, David, Yeates, Todd O.
フォーマット: Artigo
言語:Inglês
出版事項: The National Academy of Sciences 1999
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC16324/
https://ncbi.nlm.nih.gov/pubmed/10200254
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