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Assigning protein functions by comparative genome analysis: Protein phylogenetic profiles

Determining protein functions from genomic sequences is a central goal of bioinformatics. We present a method based on the assumption that proteins that function together in a pathway or structural complex are likely to evolve in a correlated fashion. During evolution, all such functionally linked p...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Pellegrini, Matteo, Marcotte, Edward M., Thompson, Michael J., Eisenberg, David, Yeates, Todd O.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16324/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10200254/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.8.4285
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