Influence of experimental rat model of multiple organ dysfunction on cefepime and amikacin pharmacokinetics.

We adapted an experimental model of multiple organ dysfunction to study the alterations it induces in the pharmacology of cefepime and amikacin. The half-lives of both antibiotics were significantly prolonged because of nonsignificant enhancement of the volume of distribution and reduced renal elimi...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Mimoz, O, Jacolot, A, Padoin, C, Quillard, J, Tod, M, Louchahi, K, Samii, K, Petitjean, O
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1996
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163210/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8851623/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.3.819
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