Influence of experimental rat model of multiple organ dysfunction on cefepime and amikacin pharmacokinetics.

We adapted an experimental model of multiple organ dysfunction to study the alterations it induces in the pharmacology of cefepime and amikacin. The half-lives of both antibiotics were significantly prolonged because of nonsignificant enhancement of the volume of distribution and reduced renal elimi...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Mimoz, O, Jacolot, A, Padoin, C, Quillard, J, Tod, M, Louchahi, K, Samii, K, Petitjean, O
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1996
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163210/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8851623/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.3.819
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