Influence of experimental rat model of multiple organ dysfunction on cefepime and amikacin pharmacokinetics.

We adapted an experimental model of multiple organ dysfunction to study the alterations it induces in the pharmacology of cefepime and amikacin. The half-lives of both antibiotics were significantly prolonged because of nonsignificant enhancement of the volume of distribution and reduced renal elimi...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Mimoz, O, Jacolot, A, Padoin, C, Quillard, J, Tod, M, Louchahi, K, Samii, K, Petitjean, O
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163210/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8851623/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.3.819
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