Use of standardized SCID-hu Thy/Liv mouse model for preclinical efficacy testing of anti-human immunodeficiency virus type 1 compounds.

We have developed standardized procedures and practices for infection of SCID-hu Thy/Liv mice with human immunodeficiency virus type 1 for the prophylactic administration of antiviral compounds and for evaluation of the antiviral effect in vivo. Endpoint analyses included quantitation of viral load...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Principais autores:	Rabin, L, Hincenbergs, M, Moreno, M B, Warren, S, Linquist, V, Datema, R, Charpiot, B, Seifert, J, Kaneshima, H, McCune, J M
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163193/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8851606/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.3.755
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