A common pharmacophore for cytotoxic natural products that stabilize microtubules
Taxol (paclitaxel), a complex diterpene obtained from the Pacific yew, Taxus brevifolia, is arguably the most important new drug in cancer chemotherapy. The mechanism of cytotoxic action for paclitaxel—i.e., the stabilization of microtubules leading to mitotic arrest—is now shared by four recently i...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16319/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10200249/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.8.4256 |
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