A common pharmacophore for cytotoxic natural products that stabilize microtubules

Taxol (paclitaxel), a complex diterpene obtained from the Pacific yew, Taxus brevifolia, is arguably the most important new drug in cancer chemotherapy. The mechanism of cytotoxic action for paclitaxel—i.e., the stabilization of microtubules leading to mitotic arrest—is now shared by four recently i...

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Bibliografski detalji

Izdano u:	Proc Natl Acad Sci U S A
Glavni autori:	Ojima, Iwao, Chakravarty, Subrata, Inoue, Tadashi, Lin, Songnian, He, Lifeng, Horwitz, Susan Band, Kuduk, Scott D., Danishefsky, Samuel J.
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 1999
Teme:	Physical Sciences
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16319/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10200249/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.8.4256
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