Anticytomegaloviral activity of methotrexate associated with preferential accumulation of drug by cytomegalovirus-infected cells.

We extend the observation that inhibitors of pyrimidine biosynthesis are active against human cytomegalovirus by demonstrating that methotrexate (MTX) has preferential activity against cytomegalovirus replication. The 50% and 90% inhibitory concentrations of MTX for inhibition of cytomegaloviral DNA...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Wachsman, M, Hamzeh, F M, Saito, H, Lietman, P S
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 1996
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC163129/
https://ncbi.nlm.nih.gov/pubmed/8834893
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