Anticytomegaloviral activity of methotrexate associated with preferential accumulation of drug by cytomegalovirus-infected cells.

We extend the observation that inhibitors of pyrimidine biosynthesis are active against human cytomegalovirus by demonstrating that methotrexate (MTX) has preferential activity against cytomegalovirus replication. The 50% and 90% inhibitory concentrations of MTX for inhibition of cytomegaloviral DNA...

Fuld beskrivelse

Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Wachsman, M, Hamzeh, F M, Saito, H, Lietman, P S
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1996
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163129/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8834893/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.2.433
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