Anticytomegaloviral activity of methotrexate associated with preferential accumulation of drug by cytomegalovirus-infected cells.

We extend the observation that inhibitors of pyrimidine biosynthesis are active against human cytomegalovirus by demonstrating that methotrexate (MTX) has preferential activity against cytomegalovirus replication. The 50% and 90% inhibitory concentrations of MTX for inhibition of cytomegaloviral DNA...

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Manylion Llyfryddiaeth

Cyhoeddwyd yn:	Antimicrob Agents Chemother
Prif Awduron:	Wachsman, M, Hamzeh, F M, Saito, H, Lietman, P S
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	American Society for Microbiology (ASM) 1996
Pynciau:	Research Article
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163129/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8834893/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.2.433
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