Effect of alpha interferon (IFN-alpha) on 2'-5' oligoadenylate synthetase activity in peripheral blood mononuclear cells of patients with chronic hepatitis C: relationship to the antiviral effect of IFN-alpha.

Alpha interferon (IFN-alpha) is, to date, the only treatment with proven efficacy in patients with chronic hepatitis C. However, less than 15% of the patients have a sustained response to IFN-alpha. Interferon acts through the induction of various cellular enzymes. Among them, the 2'-5' oligoadenyla...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Pawlotsky, J M, Hovanessian, A G, Roudot-Thoraval, F, Robert, N, Bouvier, M, Babany, G, Duval, J, Dhumeaux, D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163109/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8834873/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.2.320
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