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Identification of Tyr413 as an Active Site Residue in the Flavoprotein Tryptophan 2-Monooxygenase and Analysis of Its Contribution to Catalysis

The flavoenzyme tryptophan 2-monooxygenase catalyzes the oxidation of tryptophan to indoleacetamide, carbon dioxide, and water. The enzyme is a homologue of L-amino acid oxidase. In the structure of L-amino acid oxidase complexed with aminobenzoate, Tyr372 hydrogen bonds with the carboxylate of the...

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Detalhes bibliográficos
Main Authors: Sobrado, Pablo, Fitzpatrick, Paul F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1630680/
https://ncbi.nlm.nih.gov/pubmed/14636050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi035300i
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