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The mechanism of the flavoprotein L-6-hydroxynicotine oxidase: pH and solvent isotope effects and identification of key active site residues

The flavoenzyme L-6-hydroxynicotine oxidase (LHNO) is a member of the monoamine oxidase family that catalyzes the oxidation of (S)-6-hydroxynicotine to 6-hydroxypseudooxynicotine during microbial catabolism of nicotine. While the enzyme has long been understood to catalyze oxidation of carbon-carbon...

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Publicat a:Biochemistry
Autors principals: Fitzpatrick, Paul F., Chadegani, Fatemeh, Zhang, Shengnan, Dougherty, Vi
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312672/
https://ncbi.nlm.nih.gov/pubmed/28080034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01160
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