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The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity

p53 major tumour suppressor protein has presented a challenge for structural biology for two decades. The intact and complete p53 molecule has eluded previous attempts to obtain its structure, largely due to the intrinsic flexibility of the protein. Using ATP-stabilised p53, we have employed cryoele...

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Autors principals: Okorokov, Andrei L, Sherman, Michael B, Plisson, Celia, Grinkevich, Vera, Sigmundsson, Kristmundur, Selivanova, Galina, Milner, Jo, Orlova, Elena V
Format: Artigo
Idioma:Inglês
Publicat: 2006
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1630404/
https://ncbi.nlm.nih.gov/pubmed/17053786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601382
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