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The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity
p53 major tumour suppressor protein has presented a challenge for structural biology for two decades. The intact and complete p53 molecule has eluded previous attempts to obtain its structure, largely due to the intrinsic flexibility of the protein. Using ATP-stabilised p53, we have employed cryoele...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2006
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1630404/ https://ncbi.nlm.nih.gov/pubmed/17053786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601382 |
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