Biochemical basis for increased susceptibility to Cidofovir of herpes simplex viruses with altered or deficient thymidine kinase activity.

It has been observed that herpes simplex virus mutants with deficient or altered thymidine kinase activity are more susceptible to Cidofovir (CDV; 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine dihydrate) in tissue culture than are the parental strains. During infection of cells, the elevation...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Mendel, D B, Barkhimer, D B, Chen, M S
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162892/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8540727/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.9.2120
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