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K65R mutation of human immunodeficiency virus type 1 reverse transcriptase encodes cross-resistance to 9-(2-phosphonylmethoxyethyl)adenine.

Cloned variants of human immunodeficiency virus type 1 that contain the K65R mutation in reverse transcriptase have previously been shown to display approximately 10- to 30-fold resistance against 2',3'-dideoxycytidine, 2',3'-dideoxyinosine, and 2',3'-dideoxy-3'-thiacytidine. On the basis of tissue...

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Publicado no:Antimicrob Agents Chemother
Principais autores: Gu, Z, Salomon, H, Cherrington, J M, Mulato, A S, Chen, M S, Yarchoan, R, Foli, A, Sogocio, K M, Wainberg, M A
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162849/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7486942/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.8.1888
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