Effects of Asp-179 mutations in TEMpUC19 beta-lactamase on susceptibility to beta-lactams.
To examine the effect of disruption of the salt bridge (between Arg-164 and Asp-179 [numbering of Ambler et al. (Biochem J. 267:269-272, 1991)]) that anchors the conserved omega-loop in class A beta-lactamases, we obtained mutant enzymes with each of the 19 other amino acid residues replacing Asp-17...
Збережено в:
| Опубліковано в:: | Antimicrob Agents Chemother |
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| Автори: | , , , , |
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
American Society for Microbiology (ASM)
1995
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| Предмети: | |
| Онлайн доступ: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162846/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7486939/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.8.1878 |
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