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Effects of Asp-179 mutations in TEMpUC19 beta-lactamase on susceptibility to beta-lactams.

To examine the effect of disruption of the salt bridge (between Arg-164 and Asp-179 [numbering of Ambler et al. (Biochem J. 267:269-272, 1991)]) that anchors the conserved omega-loop in class A beta-lactamases, we obtained mutant enzymes with each of the 19 other amino acid residues replacing Asp-17...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Vakulenko, S B, Tóth, M, Taibi, P, Mobashery, S, Lerner, S A
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162846/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7486939/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.8.1878
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