Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs.

Forty-four sulfa drugs were screened against crude preparations of recombinant Pneumocystis carinii dihydropteroate synthetase. The apparent Michaelis-Menten constants (Km) for p-aminobenzoic acid and 7,8-dihydro-6-hydroxymethylpterin pyrophosphate were 0.34 +/- 0.02 and 2.50 +/- 0.71 microM, respec...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Hong, Y L, Hossler, P A, Calhoun, D H, Meshnick, S R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162822/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7486915/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.8.1756
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