Contribution of the C-8 substituent of DU-6859a, a new potent fluoroquinolone, to its activity against DNA gyrase mutants of Pseudomonas aeruginosa.

Inhibitory effects of five quinolones against DNA gyrases purified from four quinolone-resistant clinical isolates of Pseudomonas aeruginosa and the quinolone-susceptible strain PAO1 were examined. All of the quinolone-resistant strains tested were found to be DNA gyrase mutants. The 50% inhibitory...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Kitamura, A, Hoshino, K, Kimura, Y, Hayakawa, I, Sato, K
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162764/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7492087/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.7.1467
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